The Effects of Magnesium Sulphate on Rocuronium-induced Neuromuscular Block Magnezyum Sülfatin Rokuronyum ile Oluşturulan Nöromüsküler Blok Üzerine Etkileri
Turk Anesteziyoloji ve Reanimasyon Dernegi Dergisi, cilt.32, sa.1, ss.11-15, 2004 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 32 Sayı: 1
- Basım Tarihi: 2004
- Dergi Adı: Turk Anesteziyoloji ve Reanimasyon Dernegi Dergisi
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.11-15
- Anahtar Kelimeler: General anaesthesia, Magnesium sulphate, Neuromuscular block, Rocuronium
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Magnesium sulphate inhibits the release of acetylcholine from the motor nerve terminal and thus potentiates the action of the nun depolarizing neuromuscular blocking drugs. The aim of this study is to investigate the effects of magnesium sulphate on rocuronium-induced neuromuscular block. After obtaining institutional Ethics Committee approval, ASA I or II, 40 patients were stutied. All patients were premedicated with midazolam (0.05 mg kg -1; im) 30 minutes before the operation. The patients were monitored with ECG, pulse oxymetry, noninvasive blood pressure cuff, capnography, thermal probe and TOF-Guard response. TOF-Guard twitch calibration process was done. The patients were randomly seperated into two groups. Patients in Group I, MgSO4 (60 mg kg-1; iv) in saline, total amount of 100 mL was infused as an iv infusion over 15 min. Patients in group II the same volume of saline was infused without MgSO4. In both groups, anaesthesia was induced with fentanyl (1 μg kg-1; iv) and thiopentone (5 mg kg-1; iv). Rocuronium (0.6 mg kg-1; iv) was given in 5 see. Tw 0% time was detected and intubatiou was done and quality of intubation was assessed. Tw 10% and 25% recovery time and recovery index were noted. The study groups did not differ in age, sex and weight. Time of 0% Tw was significantly shorter in Group I (p<0.001). Tw 10% and 25% recovery times (p<0.01) and recovery index (p<0.001) were found longer in Group I. There was no difference in intubation quality between two groups. In conclusion; MgSO4 60 mg kg-1 increases the speed of onset and prolongs the duration of action of rocuronium-induced neuromuscular block.