A simple method for the evaluation of epidermal thickness variations in psoriasis vulgaris
Analytical and Quantitative Cytology and Histology, cilt.28, sa.4, ss.237-242, 2006 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 28 Sayı: 4
- Basım Tarihi: 2006
- Dergi Adı: Analytical and Quantitative Cytology and Histology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.237-242
- Anahtar Kelimeler: epidermal thickness, image analysis, psoriasis
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
OBJECTIVE: To evaluate the "variation" of the epidermal thickness and variables such as the mean, maximum, and minimum thickness for the diagnosis and follow-up of some skin diseases such as psoriasis. STUDY DESIGN: A simple quantitative method is described. A series of psoriasis vulgaris cases is provided as an example. Biopsy samples taken before and after topical treatment were used. RESULTS: The mean thickness was higher in lesions compared to the perilesional control skin (p < 0.001) and post-treatment lesional area (p < 0.001). CONCLUSION: The thickness of the epidermis varies due to a multitude of factors. Measuring the mean epidermal thickness may be important. However, this measurement may not be the best way for studies involving a series of patients and a variety of lesion sites. The natural variations in the thickness of the epidermis of different body sites and of different persons may prevent the usage of thickness measurements alone on a wider scale. It is hoped that this method can be used for evaluation of certain skin diseases affecting epidermal thickness where variation of the epidermal thickness is a potentially useful diagnostic and therapeutic variable. © Science Printers and Publishers, Inc.