The l-Arginine/Asymmetric Dimethylarginine (ADMA) Ratio in Health and Disease: An Overview
Nutrition and Health (United Kingdom), Palgrave Macmillan, ss.225-238, 2017
- Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
- Basım Tarihi: 2017
- Doi Numarası: 10.1007/978-3-319-26009-9_18
- Yayınevi: Palgrave Macmillan
- Sayfa Sayıları: ss.225-238
- Anahtar Kelimeler: ADMA, Asymmetric dimethylarginine, l-Arginine, l-Arginine/asymmetric dimethylarginine ratio, Nitric oxide
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Endothelium is acting a vital role in the control of tonus of vasculature and homeostasis (Widlansky et al., J Am Coll Cardiol 42:1149–1460, 2003). Although the significance of endothelial dysfunction has been well described by many published studies, especially in cardiovascular diseases, so far, there are some challenges in the evaluation of endothelial function due to lack of a standardization. Nitric oxide (NO) is mainly released by the endothelium and plays a critical role in the maintenance of normal endothelial function by regulating the vascular tone (Pacher et al., Physiol Rev 87:315–424, 2007). Inactivation and/or reduced synthesis of NO leads to endothelial dysfunction, whereas an excess of NO may cause circulatory shock (Forstermann, Pflugers Arch 459:923–939, 2010). In addition, NO modulates the interactions of circulating blood cells with the vascular wall, which are the key processes involved in the pathogenesis of atherosclerosis such as adhesion of inflammatory cells to the vascular wall, the aggregation of platelets, and the proliferation of smooth muscle cells (Moncada and Higgs, Br J Pharmacol 147:S193–S201, 2006). Therefore, NO bioavailability is more important and has recently been used as an indicator of endothelial function.