The effects of oxytocin and carbetocin on hemostatic parameters in women after spontaneous vaginal delivery: a randomized trial
Revista da Associacao Medica Brasileira, cilt.72, sa.2, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 72 Sayı: 2
- Basım Tarihi: 2026
- Doi Numarası: 10.1590/1806-9282.20251346
- Dergi Adı: Revista da Associacao Medica Brasileira
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
- Anahtar Kelimeler: Carbetocin, Oxytocin, Labor, obstetric, Postpartum hemorrhage
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
OBJECTIVE: This prospective randomized study compared the effects of two uterotonic drugs, oxytocin and carbetocin, on hemostatic parameters in patients undergoing spontaneous vaginal delivery. METHODS: One hundred women aged between 18 and 40 years, with term singleton pregnancies who underwent spontaneous vaginal delivery were enrolled in the study. Women with induced labor, preterm deliveries, multiple pregnancies, hypertension, macrosomia, polyhydramnios, and chronic disease were excluded. When women are admitted to the delivery room during the active phase of labor, eligible participants were randomly allocated in a 1:1 ratio to either oxytocin or carbetocin group. Following spontaneous vaginal delivery, the postpartum hemorrhage prophylaxis was provided with an intravenous infusion of 20 units of oxytocin in 1,000 mL ringer lactate solution for 2 h in the oxytocin group, and an intravenous infusion of 100 μg carbetocin in the carbetocin group. Maternal demographic and obstetric characteristics were recorded. Blood samples were collected just before vaginal delivery (T0), 2 h (T1) and 24 h (T2) following uterotonic infusion. Blood count, coagulation profile including D-dimer, fibrinogen, international normalized ratio, prothrombin time, and activated partial thromboplastin time were measured. Results were compared between groups using appropriate statistical tests. RESULTS: Serum levels of hemoglobin, platelet counts, prothrombin time, activated partial thromboplastin time, fibrinogen, D-dimer, and international normalized ratio measured at all time points were similar between groups (p>0.05). No serious side effects were observed in any patient. CONCLUSION: Slow infusion of oxytocin and carbetocin has comparable effects on hemostatic parameters with similar efficacy and with no clinically significant side effects.