Effect of modern surgical treatment on the inflammatory/anti-inflammatory balance in patients with obstructive sleep apnoea

Binar M., Akcam T., Karakoc O., Sagkan R., Musabak U., GEREK M.

Journal of Laryngology and Otology, cilt.131, sa.8, ss.719-727, 2017 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Özet
  • Cilt numarası: 131 Sayı: 8
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1017/s0022215117001116
  • Dergi Adı: Journal of Laryngology and Otology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.719-727
  • Anahtar Kelimeler: Obstructive Sleep Apnea, Inflammation, Surgical Procedures, Operative, Continuous Positive Airway Pressure, Cytokines
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Objective: To investigate the inflammatory/anti-inflammatory cytokine balance - T helper 1/T helper 2 ratios - in obstructive sleep apnoea patients, before and after treatment. Methods: Twenty-eight patients received continuous positive airway pressure treatment and 29 patients who could not tolerate continuous positive airway pressure were scheduled for surgery. Serum levels of interleukins 2, 4 and 10, tumour necrosis factor-Alpha, and interferon gamma were analysed by enzyme-linked immunosorbent assays before and three months after treatment. Results: The success rate of surgical treatment was 65.5 per cent. Mean compliance for the continuous positive airway pressure group was 40.9 per cent. The apnoea/hypopnoea index significantly decreased in both groups after treatment (p < 0.001). The interferon gamma/interleukin-4 ratio decreased following surgical treatment (p = 0.014), and the interleukin-2/interleukin-4 ratio decreased after treatment in 57 patients in the overall cohort (p = 0.032). Conclusion: After treatment for obstructive sleep apnoea, some ratios reflecting T helper 1/T helper 2 cytokine balance favoured the T helper 2 direction, suggesting a shift to an anti-inflammatory state. Successful surgery and better continuous positive airway pressure compliance can help ameliorate inflammation in obstructive sleep apnoea patients, which may reduce associated morbidities.