The relationship between anti-mullerian hormone and androgens in healthy women without hyperandrogenemia Hiperandrojenemisi olmayan sağlıklı kadınlarda anti-müllerian hormon ile androjenlerin ılişkisi
Medeniyet Medical Journal, cilt.34, sa.1, ss.20-26, 2019 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 34 Sayı: 1
- Basım Tarihi: 2019
- Doi Numarası: 10.5222/mmj.2019.37980
- Dergi Adı: Medeniyet Medical Journal
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.20-26
- Anahtar Kelimeler: Androgen, Androstenedione, Anti-mullerian hormone, Dehydroepiandrosterone, Testosterone
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aim: To determine the relationship between androgens and Anti-Mullerian Hormone in healthy women without hyperandrogenemia. Methods: A total of 1300 patients aged 16-43 whose Anti-Mullerian Hormone and androgen profiles were analysed for a period of three years in a university hospital were included in the study. Socio-demographic features, clinical and sonographic findings, serum prolactin, luteinizing hormone, total and free testosterone, estradiol, thyroid stimulating hormone, follicle stimulating hormone, 17-hydroxy progesterone, dehydroepiandrosterone and Anti-Mullerian Hormone levels were recorded. Patients were selected according to inclusion and exclusion criteria and the study was completed with 337 patients. Results: The mean age of the patients was 28.82±5.24 years and body mass index was 25.49±4.37 kg/m2. Mean levels of follicle stimulating hormone, luteinizing hormone and estradiol were 6.82±4.71 mIU/mL, 5.59±3.78 mIU/mL and 40.77±36.28 pg/mL, respectively. When the androgen profiles were evaluated, the mean total testosterone, free testosterone, 17-hydroxy progesterone, androstenedione and dehydroepiandrosterone levels were detected as 47.36±33.09 pg/mL, 2.61±2.54 pg/mL, 0.65±0.20 ng/mL, 2.43±1.25 ng/mL and 244.45±115.87 mcg/dL, respectively. The mean Anti-Mullerian hormone levels were 4.43±4.70 ng/mL. A significant independent relationship was found between Anti-Mullerian hormone and luteinizing hormone (p=0.009), follicle stimulating hormone (p=0.001), androstenedione (p=0.050), dehydroepiandrosterone (p=0.034) and body mass index (p=0.021). Anti-Mullerian hormone levels were affected by follicle stimulating hormone and body mass index negatively; while luteinizing hormone, androstenedione and dehydroepiandrosterone affect its levels positively. Conclusion: According to the results of this study, even in patients who have not hyperandrogenemia or not diagnosed as late-onset congenital adrenal hyperplasia or polycystic ovary syndrome, androstenedione (a precursor of testosterone) and dehydroepiandrosterone may increase Anti-Mullerian hormone levels.