The Prognostic Significance of Tumor SUVmax Value in Pre‑ and Post‑Chemoradiotherapy 18F‑FDG PET/CT Imaging in Patients with Localized and Advanced Head and Neck Squamous Cell Carcinoma
Nigerian Journal of Clinical Practice, cilt.27, sa.6, ss.748-753, 2024 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 27 Sayı: 6
- Basım Tarihi: 2024
- Doi Numarası: 10.4103/njcp.njcp_856_23
- Dergi Adı: Nigerian Journal of Clinical Practice
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.748-753
- Anahtar Kelimeler: Chemoradiotherapy, head and neck cancer, maximum standardized uptake value, positron emission tomography, squamous cell carcinoma
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: Some parameters of 18F‑2‑fluoro‑2‑deoxy‑D‑glucose positron emission tomography/computed tomography (18F-FDG PET/CT) can predict tumor chemosensitivity and survival in patients with head and neck squamous cell carcinoma (HNSCC). Aim: The aim of the study was to investigate the prognostic value of pre- and post-treatment maximum standardized uptake values (SUVmax) in 18F-FDG PET/CT imaging for predicting mortality in patients with HNSCC, as well as its prognostic value in terms of disease progression, overall survival (OS), and progression-free survival (PFS). Methods: This retrospective study included 37 patients with a histopathological diagnosis of HNSCCs between 2015 and 2018. In patients with HNSCC, the first 18F-FDG PET/CT imaging was performed for pre-treatment staging, and the second imaging was performed to evaluate post-treatment response. In these imaging studies, SUVmax values of the primary tumor before and after treatment were determined. After the second imaging, patients were re-evaluated and followed up. ROC analysis was used to determine the predictive value of 18F-FDG PET/CT SUVmax parameters in terms of death and progression, and Cox regression analysis was used to investigate the prognostic value in terms of OS and PFS. Results: Cut‑off value 15 for SUVmax1 (pre‑treatment) had a significant predictive value for mortality (P = 0.02). Cut‑off value 3.1 for SUVmax2 (post‑treatment) had a significant predictive value for progression (P = 0.024). In univariate analysis, both SUVmax1 and SUVmax2 values were significant prognostic factors for OS (P = 0.047, P = 0.004). However, for PFS, only the SUVmax2 value was a significant prognostic factor (P = 0.001). Conclusion: SUVmax1 value of the primary tumor at diagnosis in HNSCC patients has a predictive value for mortality and a prognostic value for OS. However, the SUVmax2 value in the primary tumor after treatment is a predictive factor for progression and a prognostic factor for both OS and PFS.