Evaluation of Vitamin D levels in patients with breast cancer-related lymphedema: An observational cross-sectional study Meme Kanseri İlişkili Lenfödem Hastalarında Vitamin D Düzeylerinin Değerlendirilmesi: Kesitsel Gözlemsel Araştırma
Turk Osteoporoz Dergisi, cilt.25, sa.3, ss.105-110, 2019 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 25 Sayı: 3
- Basım Tarihi: 2019
- Doi Numarası: 10.4274/tod.galenos.2019.35119
- Dergi Adı: Turk Osteoporoz Dergisi
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.105-110
- Anahtar Kelimeler: Vitamin D, breast cancer, lymphedema, parathormone
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: The aim of our study was to compare plasma vitamin D levels between patients with breast cancer-related lymphedema (BCRL) and healthy population, and also to investigate the effects of socio-demographic and clinical factors and lymphedema severity on vitamin D levels. Materials and Methods: Eighty patients with BCRL [mean age 55.5±8.9 (36-81)] and age- and sex-matched 80 healthy controls [mean age 53.7±7.4 (32-70)] who were not on calcium or vitamin D supplementation were included in the study. Socio-demographic and clinical characteristics of the subjects were questioned. Plasma 25-Hydroxyvitamin D3, calcium, phosphorus, alkaline phosphatase (ALP), and parathormone (PTH) levels were evaluated. Lymphedema was classified as stage 0, I, II, or III. Results: The mean duration of lymphedema was 23.5±13.8 months. Comparisons revealed lower vitamin D levels and higher PTH and ALP levels in patients with BCRL than healthy controls. As a result of multivariate regression analysis, a significant relationship was revealed between vitamin D levels and age, breast cancer stage, and disease duration in patients with BCRL. Vitamin D levels were significantly lower and PTH levels were significantly higher in stage 3 lymphedema patients compared to stage 1. Conclusion: Vitamin D levels were detected lower in patients with lymphedema than healthy controls. Although vitamin D levels were found to be lower in patients with severe lymphedema, the multivariate regression analysis revealed that the severity of lymphedema does not have a significant effect on vitamin D levels.