Intravitreal bevacizumab for diabetic macular edema previously treated with focal laser photocoagulation
Retina-Vitreus, cilt.26, sa.3, ss.246-249, 2017 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 26 Sayı: 3
- Basım Tarihi: 2017
- Dergi Adı: Retina-Vitreus
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.246-249
- Anahtar Kelimeler: Bevacizumab, Diabetic retinopathy, Laser photocoagulation, Macular edema, Optical coherence tomography
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Our study aimed to analyze the effi cacy of intravitreal bevacizumab (IVB) therapy on visual acuity and macular thickness in patients previously treated by focal laser photocoagulation (FLP) and who did not respond or only partially responded to this treatment. Materials and Methods: Medical records comprising 40 eyes of 32 patients treated with IVB who previously underwent FLP due to diabetic macular edema (DME) but diagnosed as clinically signifi cant macular edema (CSME), or those with.250 Êm central macular thickness (CMT) were analyzed retrospectively. Outcome measures were the change in mean best corrected visual acuity (BCVA) and CMT during the one year follow-up period. Results: Mean CMT were 403.64 ± 118.34 μm and 319.39 ± 99.57 μm before and after treatment, respectively. CMT was signifi cantly reduced at the last follow-up visit (p = 0.0001) compared to the baseline. Pre-treatment and post-treatment Log MAR values were 0.45 (range 0.20-0.95) and 0.50 (range 0.30-1.00) before and after treatment. The difference was not signifi cant (p> 0.05). Conclusion: This study suggests that if the treatment is initiated as prompt FLP and is followed by IVB therapy, good anatomic results may be obtained however; functional benefi t may not be observed. Anti-vascular endothelial growth factor (VEGF) therapy should be the fi rst treatment in diabetic macular edema or be initiated immediately in patients who had FLP treatment before in order to have at least better anatomic results.