Long-term methylphenidate treatment causes increased superoxide dismutase activity and unchanged lipid peroxidation in rat brain
Klinik Psikofarmakoloji Bulteni, cilt.16, sa.2, ss.79-83, 2006 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 16 Sayı: 2
- Basım Tarihi: 2006
- Dergi Adı: Klinik Psikofarmakoloji Bulteni
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.79-83
- Anahtar Kelimeler: Antioxidant system, Malondialdehyde, Methylphenidate
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Methylphenidate (MP) is commonly used to treat children and adolescents with attention-deficit/hyperactivity disorder. However, MP still poses a number of questions of whether it has toxic effects of long term treatment on the brain. In the present study, the effect of MP was investigated on the antioxidant system and lipid peroxidation with the purpose of evaluating its toxic effects on the brain. Methods: MP at a dose of 10 mg/kg via orogastric intubation was administered to rats (n=10) daily for 8 weeks, whereas control rats (n=10) were given distilled water via oragastric intubation. CuZn-superoxide dismutase (CuZn-SOD), Se-glutathione peroxidase (Se-GPx), and malondialdehyde (MDA) were measured in rat brains. Results: Brain CuZn-SOD activities were higher in the study group when compared with the controls (p < 0.01), but there were no significant differences in brain Se-GPx activities and MDA levels of the groups (p > 0.05). Conclusions: Long-term MP treatment, which seems to interact with antioxidant enzymes, causes 1.2 fold increase in the activity of CuZn-SOD. However, it does not noticeably influence the activity of GPx, and the level of MDA in rat brains. -It seems possible that free radicals by MP administration neutralize sufficiently by increasing SOD levels and does not cause lipid peroxidation in the brain.