3D printed 13-93B3 borate bioactive glass/hydroxypropyl methyl cellulose/gelatin scaffolds with cerium oxide submicrometric particles for potential bone regeneration
Biomedical Materials (Bristol), cilt.21, sa.3, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 21 Sayı: 3
- Basım Tarihi: 2026
- Doi Numarası: 10.1088/1748-605x/ae67c9
- Dergi Adı: Biomedical Materials (Bristol)
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, Compendex, EMBASE, INSPEC, MEDLINE
- Anahtar Kelimeler: CeO2 submicrometric particles, antibacterial properties, biomineralization, bioactive glass, bioactivity
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
In this study, a novel hydroxypropyl methyl cellulose (HPMC)/gelatin composite scaffold was prepared by incorporating 13–93B3 borate bioactive glass (BBG) microparticles and cerium oxide (CeO₂) submicrometric particles as a discrete phase, enabling higher ceria loadings without disrupting the bioactive glass chemistry. Composite hydrogel inks containing 5 wt% BBG microparticles and up to 20 wt% submicrometric CeO2 particles were successfully extrusion-printed into porous scaffolds with interconnected pore architecture. CeO2 incorporation preserved printability and mechanical strength while significantly enhancing scaffold deformation ability. Degradation behavior was tunable, with BBG microparticles reducing swelling and CeO2 submicrometric particles modulating water uptake and pH evolution. BBG microparticles and CeO2 submicrometric particles synergistically promoted apatite formation following 7 d of SBF incubation. In vitro studies using MC3T3-E1 pre-osteoblasts confirmed high cytocompatibility and Alizarin red study showed enhanced mineralization in CeO2-containing scaffolds. Additionally, BBG and CeO2 incorporated scaffolds exhibited strong antibacterial activity against S. aureus and E. coli. Overall, this multifunctional scaffold platform demonstrates promise for bone tissue engineering applications.