Predictors of aortic regurgitation and dilatation in children with bicuspid aortic valve
Annals of Pediatric Cardiology, cilt.18, sa.4, ss.345-350, 2025 (ESCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 18 Sayı: 4
- Basım Tarihi: 2025
- Doi Numarası: 10.4103/apc.apc_87_25
- Dergi Adı: Annals of Pediatric Cardiology
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, CINAHL, EMBASE, Directory of Open Access Journals
- Sayfa Sayıları: ss.345-350
- Anahtar Kelimeler: Aortic regurgitation, aortic root dilatation, bicuspid aortic valve, children
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: Aortic root and ascending aorta dilatations, along with aortic regurgitation (AR), are prevalent and significant causes of morbidity and mortality in patients with a bicuspid aortic valve. This study investigated the impact of valve morphology, aortic shape, ventricular function, aortic measurements, and serum pro-B-type natriuretic peptide (BNP) levels on AR and dilatation. Materials and Methods: The study included 126 patients, grouped based on the degree of valve regurgitation. Demographic and clinical characteristics, serum pro-BNP levels, and echocardiographic measurements were recorded for all patients. Valve morphology, aortic structure, diameters of the aortic root, ascending and descending aorta, ventricular function, and pro-BNP results were analyzed. Results: The most frequent valve morphology was cusp fusion, observed in 90 patients (71.4%). In terms of valve morphology, patients with cusp fusion exhibited a higher incidence of moderate AR compared to those with a pure bicuspid valve (P = 0.022). Significant differences in z-scores for the arch, isthmus, and descending aorta were found between valve shapes, with right-noncoronary cusp fusion patients showing higher z-scores (P = 0.005, P = 0.047, P = 0.011, respectively). The mean age and left ventricular diastolic diameter z-scores were higher in the tubular aortic phenotype group (P = 0.037 and P = 0.007, respectively). Conclusion: Patients with right-noncoronary cusp fusion should be closely monitored for aortic aneurysm and AR risk, and early preventive treatment should be initiated in these cases.