The clinical impact and use of metabolomics in diabetes research
Metabolomics and Clinical Approach, NOVA Publications , ss.123-133, 2023
- Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
- Basım Tarihi: 2023
- Yayınevi: NOVA Publications
- Sayfa Sayıları: ss.123-133
- Anahtar Kelimeler: Biomarkers, Cardiovascular disease, Chronic kidney disease, Metabolomics, Type 2 diabetes
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Diabetes mellitus is a chronic metabolic disease in which hyperglycemia results from insulin resistance and reduced insulin, as in type 2 diabetes (T2D), or destruction of insulin-producing pancreatic β-cells as in type 1 diabetes (T1D). The mortality rate is higher in the diabetes population than in the general population, largely owing to cardiovascular and renal complications. Recent studies have shown that the only essential factor is the patient, not the disease. The genomic structure of each patient shapes the disease in its unique way. In this determination, an-omic identity emerges. The application of metabolomics in diabetes has simplified the identification of metabolites that can serve as screening and prognostic biomarkers. Metabolomic studies on diabetic subjects demonstrated many altered metabolic pathways and variations. Identifying predictive biomarkers involved in the pathogenesis of diabetes is essential, and avoiding complications related to personalized phenotyping and individualized drug response are recent study subjects. So, it is aimed to review the use of metabolomics and its impacts on diabetes research in this chapter.