Successful Meropenem Desensitization in an Elderly Patient With Meropenem Hypersensitivity
Asthma Allergy Immunology, cilt.24, sa.1, ss.119-122, 2026 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 24 Sayı: 1
- Basım Tarihi: 2026
- Doi Numarası: 10.21911/aai.2026.1241
- Dergi Adı: Asthma Allergy Immunology
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.119-122
- Anahtar Kelimeler: Meropenem, desensitization, drug allergy
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Drug desensitization enables essential treatment in patients with drug hypersensitivity when alternatives are unavailable. We describe an 81-year-old woman with chronic renal failure and malignancies who developed a Klebsiella pneumoniae infection. She had a remote, unconfirmed history of a penicillin-associated adverse reaction and experienced an immediate hypersensitivity reaction to meropenem. Given her age and comorbidities, direct 12-step meropenem desensitization was performed without prior testing. During the final step, urticaria occurred but was controlled, and therapy was completed after adding an intermediate step. The patient tolerated the full dose without further reaction. This case illustrates the safety and effectiveness of individualized meropenem desensitization in high-risk elderly patients.