The effect of pentoxifylline on renal ischemia and reper-fusion damage Böbrek iskemi reperfüzyon hasarinda pentoksifilinin etkisi
Cocuk Cerrahisi Dergisi, cilt.24, sa.1, ss.1-6, 2010 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 24 Sayı: 1
- Basım Tarihi: 2010
- Dergi Adı: Cocuk Cerrahisi Dergisi
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.1-6
- Anahtar Kelimeler: Oxidative stress, Pentoxifylline, Renal ischemia and reperfusion
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aim: To investigate the effect of pentoxifylline (Ptx) on oxidative and antioxidative status in the renal ischemia and reperfusion (I/R). Method: Twenty four Wistar albino rats were used for the study. Rats were divided into four categories as control, ischemia, I/R and I/R plus Ptx administration groups. Blood samples and renal tissue specimes were obtained from rats after the operations. As oxidants malondialdehyde (MDA) and total peroxide levels, and total antioxidants capacity (TAOC) were measured from the samples. The results were analyzed statistically. In addition, renal tissue sepcimens were examined histopathologically. Results: Decreased blood and renal tissue MDA and t-prx levels were found to be significantly lower in ptx group when compared with other groups (p<0.05). Blood TAOC levels in Ptx group were significantly lower than control and I/R groups. No significant difference was found in tissue TAOC levels between groups. Histopathologically, in the I/R group. kidneys were found to be damaged. Conclusions: The oxidative stress and renal damage after renal I/R were found to be more severe relative to ischemic harm. However this damage could be reduced by Ptx ad-ministration.