Identifying the predictors of estimated glomerular filtration rate after partial nephrectomy with a nonlinear regression model
International Journal of Clinical Practice, cilt.75, sa.3, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 75 Sayı: 3
- Basım Tarihi: 2021
- Doi Numarası: 10.1111/ijcp.13763
- Dergi Adı: International Journal of Clinical Practice
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, CINAHL, EMBASE, International Pharmaceutical Abstracts, MEDLINE
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Purpose: To evaluate the effect of partial nephrectomy on renal function and to identify predictors of estimated glomerular filtration rate (eGFR) at 6 months after partial nephrectomy. Methods: Medical data of 154 consecutive patients who underwent partial nephrectomy for a renal mass between January 2015 and March 2020 were retrospectively analysed. The primary outcome measure was eGFR at 6 months postoperatively. An ordinary least regression analysis using a restricted cubic spline for continuous variables was performed to examine the association between primary outcome measure and candidate predictors. Results: Of the patients, 66 (42.9%) were females and 88 (57.1%) were males with a median age of 60 (range, 50 to 67) years. The median baseline eGFR was 90.40 (range, 74.96 to 102.97) mL/min/1.73 m2, while the median eGFR at 6 months was 77.12 (range, 61.06 to 91.93) mL/min/1.73 m2 (P <.001). Baseline eGFR (regression coefficient (β) = 22.7, 95%CI: 18.8 to 26.5, P <.001) was found to be most significant predictor with the postoperative eGFR levels at 6 months. In addition, advanced tumour size (β = −3.17, 95%CI: −5.33 to −1.01, P <.001) and presence of hypertension (β = −3.48, 95%CI: −6.96 to −0.003, P =.049) were also found to be inversely associated with the postoperative eGFR levels at 6 months. Conclusion: Baseline eGFR values, tumour size, and presence of hypertension are significant predictors of eGFR values in the mid-term in patients undergoing partial nephrectomy.