Response to hepatitis B vaccine in patients with non-hepatitis B chronic liver disease Hepatit B disi etyolojili kronik karaciger hastaliklarinda hepatit B asisina immun cevap
Turkish Journal of Gastroenterology, cilt.8, sa.2, ss.148-151, 1997 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 8 Sayı: 2
- Basım Tarihi: 1997
- Dergi Adı: Turkish Journal of Gastroenterology
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.148-151
- Anahtar Kelimeler: chronic liver disease, hepatitis B vaccine
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Patients with chronic liver disease and liver transplant recipients are at increased risk of viral hepatitis B due to medical procedures and frequent hospitalization. Vaccination against hepatitis B appears to be an important precautionary measure in these patients. On the other hand, chronic liver disease is frequently associated with some immune defects, causing failure in producing immune response to vaccines. To investigate this subject, 43 patients with non-HBV chronic liver disease (cryptogenic 15, hepatitis C-related 11, primary biliary cirrhosis 6, alcoholic cirrhosis 5 and miscellaneous 6) were vaccinated with a recombinant-preS vaccine (Gen Hevac-Pasteur Merieux, Paris; 20 u/0,5 ml, 3 doses in 3 months) and an additional dose was injected in patients whose anti-HBs titers were < 10 mIU/ml, one month after the third dose. Twenty-six patients (60.5%) responded to the HBV vaccine by developing anti-HBs titer > 10 mIU/ml. Three of the responders developed anti-Hbs titer > 10 mIU/ml after the forth dose of vaccine. Females youth (< 40 years) and child's grade A were associated with good response to vaccination as 94% of Child's A patients developed positive response. There was no correlation between the etiology of liver disease and the response to HBV vaccine. The results of this study have shown that patients with non-HBV chronic liver disease, in particular Child's A patients, have a good response to HBV vaccination, irrespective of the etiology of liver disease, whereas Child's B and Child's C patients have a significantly low response to HBV vaccine due probably to immune defects related to severe hepatocellulary failure.