Association Between Interleukin 1 Beta (IL-1β) Gene Variation and Temporal Lobe Epilepsy with Hippocampal Sclerosis Interlökin 1 Beta (IL-1β) Gen Varyasyonu ile Hippokampal Sklerozlu Temporal Lob Epilepsisi İlişkisi
Turk Noroloji Dergisi, cilt.27, sa.4, ss.390-393, 2021 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 27 Sayı: 4
- Basım Tarihi: 2021
- Doi Numarası: 10.4274/tnd.2021.70962
- Dergi Adı: Turk Noroloji Dergisi
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.390-393
- Anahtar Kelimeler: IL-1beta, temporal lobe epilepsy, hippocampal sclerosis, epilepsy, genetics
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: We aimed to determine the association between a polymorphism in the promoter region of the IL-1beta gene resulting in enhanced gene transcription and the clinical phenotype of temporal lobe epilepsy with hippocampal sclerosis (TLE+HS). Materials and Methods: The frequency of a single nucleotide polymorphism (SNP) that results in a C>T transition of 511 base pairs that are five prime to the transcription start site of the IL-1beta gene in a group of 21 patients with TLE+HS, 21 patients with temporal lobe epilepsy without hippocampal sclerosis (TLE-HS), and 23 healthy volunteers. Results: The frequency of the-511T allele was 11/21 in the TLE-HS group, 13/21 in the TLE+HS group, and 12/23 in the control group. Chi-square analysis of genotype and allele distribution showed no significant difference between the patients in TLE+HS, TLE-HS, and control group. Conclusion: There was no association between the-511/C>T SNP variation and TLE+HS.