The effect of halothane, isoflurane and propofol anaesthesia on the endocrine and metabolic responses HALOTAN, IZOFLURAN VE PROPOFOL ANESTEZISININ ENDOKRIN VE METABOLIK YANIT UZERINE ETKILERI
Turk Anesteziyoloji ve Reanimasyon, cilt.24, sa.9, ss.413-418, 1996 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 24 Sayı: 9
- Basım Tarihi: 1996
- Dergi Adı: Turk Anesteziyoloji ve Reanimasyon
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.413-418
- Anahtar Kelimeler: Inhalation anaesthesia, Stress response, TIVA
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
This study aimed to compare the effects of three different anaesthetic agents on stress response, documenting certain well-known parameters simultaneously. 30 patients were divided into three groups, and none received premedication. Induction was provided with 2-2.5 mg/kg propofol, and relaxation with 0.1 mg/kg vecuronium, intravenously. Maintenance was done with 1 % isoflurane - 30/70 O2/N2O for group I (n=10); infusion of propofol (9 mg/kg/hr for the first 30 min and 6 mg/kg/hr later) - 30/70 O2/N2O for group II (n=10); and 1 % halothane - 30/70 O2/N2O for group III (n=10). All groups received maintenance doses of vecuronium bromide. Blood samples were collected as control, anaesthesia, anaesthesia plus surgery, and at 2 hr postoperatively. Total protein, albumin, glucose, growth hormone, and cortisol levels of the blood samples were assessed. Mean blood pressures and heart rates were recorded as central, post-induction, and post-intubation. Duration of postoperative recovery time, and the incidence of postoperative nausea-vomiting were evaluated. Mean blood pressure and heart rate increased significantly following intubation in all three groups, with respect to their control levels (p<0.05). In all groups, blood glucose levels rose significantly above control values, at all times (p<0.05). Albumin levels decreased significantly in group I and II (p<0.05), while it remained stable in group III. Cortisol levels rose significantly during anaesthesia+surgery in all groups. Total protein levels followed an unsteady pattern, generally being prone to decrease. Growth hormone levels were significantly elevated in some groups. Recovery time was shortest in the propofol group, while significant differences did not exist between the groups regarding postoperative nausea and vomiting. It was concluded that these three agents lacked significant differences comparing their effects on the above parameters indicating, to some extent, the stress response.