AN OVERVIEW OF CURRENT RESEARCH ON THE DEVELOPMENT OF ANTHRAQUINONES AS ANTICANCER AGENTS ANTRAKİNONLARIN ANTİKANSER AJANLARI OLARAK GELİŞTİRİLMESİNE YÖNELİK GÜNCEL ARAŞTIRMALARA GENEL BİR BAKIŞ
Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.50, sa.3, ss.879-893, 2026 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 50 Sayı: 3
- Basım Tarihi: 2026
- Doi Numarası: 10.33483/jfpau.1714226
- Dergi Adı: Ankara Universitesi Eczacilik Fakultesi Dergisi
- Derginin Tarandığı İndeksler: Scopus, Central & Eastern European Academic Source (CEEAS), TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.879-893
- Anahtar Kelimeler: Anthracycline, anthraquinone, anticancer activity, chemical modification
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: In this study, some scientific studies on anthraquinone compounds that have been synthesized in recent years and have been found to have high in vitro and in vivo anticancer activity are summarized. It is aimed to contribute to the design and development of new anthraquinone derivative drugs that are more effective in cancer treatment and can overcome drug resistance. Result and Discussion: Anthraquinones are a privileged class of compounds that can be obtained from natural and synthetic sources and have anticancer properties with versatile mechanisms. Anthracyclines, which are potent topoisomerase inhibitors, are members of this class that are frequently used in cancer chemotherapy. Literature data suggest that new anthraquinone derivatives developed through structural modifications can exhibit better antiproliferative activity against resistant cancer cells than currently existing anthracyclines and may be more effective antitumor drug candidates.