Association between endometriosis and ovarian cancer Endometriozis ve over kanseri arasindaki ilişki
Turk Jinekolojik Onkoloji Dergisi, cilt.18, sa.4, ss.119-126, 2015 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 18 Sayı: 4
- Basım Tarihi: 2015
- Dergi Adı: Turk Jinekolojik Onkoloji Dergisi
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.119-126
- Anahtar Kelimeler: ARID1A, Endometriosis, Epithelial Ovarian Cancer
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Endometriosis is a benign hormone-dependent condition and a common gynecologic disorder, with an estimated frequency of approximately 10% among women of reproductive age. The association between endometriosis and epithelial ovarian cancer has been supported by years of epidemiologic research. Epidemiologic studies have shown an increased risk of epithelial ovarian cancer, especially endometrioid and clear cell histologies, among women with endometriosis. Approximately 1.0 % of women with endometriosis may undergo malignant transformation. Endometriosis shares several genetic characteristics with ovarian cancer. A tumor suppressor gene ARID1A (AT-rich interactive domain 1A (SWI-like)) as frequently disrupted in endometriosis-associated ovarian cancer and clear cell and endometrioid adenocarcinomas. The same pathophysiology (immune alterations, excess oxidative stress and inflammation, estrogen excess, and steroid hormone interaction) orchestrates the progression of endometriosis and its transformation to ovarian cancer. These facts show that some endometriosis has been shown to undergo malignant transformation. Ovarian cancer precursor lesions are known to be atypical endometriosis, which was identified in about 50% of these histologic subtypes.