Comparison of intrathecal clonidine and alfentanil INTRATEKAL ALFENTANIL VE KLONIDIN
Agri Dergisi, cilt.8, sa.2, ss.20-25, 1996 (Scopus)
- Yayın Türü: Makale / Özet
- Cilt numarası: 8 Sayı: 2
- Basım Tarihi: 1996
- Dergi Adı: Agri Dergisi
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.20-25
- Anahtar Kelimeler: Alfentanil, Clonidine, Spinal
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Recently adrenergic agonists and opioids have been added to local anesthetic solution to prolong spinal blockade and achieve postoperative analgesia (1). Therefore, in our study we aimed to compare the effects of intrathecal clonidine and alfentanil on spinal anesthesia and postoperative analgesia. Following hospital ethical committee approval and patient informed consent; 20 ASA I-II patients, scheduled for lower extremity surgery, were randomly assigned to two groups. In the lateral decubitus position at L4-5 spinal block was performed by clonidine 100 μg and alfentanil 100 μg both in 2.5 ml %0.5 bupivacaine in Group I and II, respectively. Systolic, diastolic and mean arterial pressures, heart and respiratory rates, arterial oxygen saturation and sedation scores (1=awake, 2=eyes closed, responds when spoken to, 3=eyes closed, responds to touch 4=waken up only after stronger tactile or acoustic stimuli) were recorded before and 5, 15, 30, 45 and 60 min after spinal anesthesia. 2, 4, 6, 12 and 24 hours following the reversal of motor blockade postoperative analgesia was evaluated by visual analogue scale (VAS). Pethidine 25 mg IV was given when the VAS scores were 5 or up. Total analgesic requirement for 24 hours was assessed. Data was analyzed using ANOVA and p<0.05 was considered as significant. The two study groups were comparable with respect to age, weight and height. While the onset of motor blockade was longer in the alfentanil group (10.9 ± 3.7, 15.4 ± 2.9 min), no statistical difference was observed in the duration of motor blockade (263 ± 22.26 230.5 ± 19.24 min). SAP, MAP, DAP and respiratory rate showed significant decreases after spinal anesthesia in both groups. While a decrease was observed in arterial oxygen saturation, sedation scores increased up to 30 min in the alfentanil group. VAS scores on the 4th and 12th hours and total pethidine requirement for 24 hours were found significantly higher in the alfentanil group. Consequently, we conclude that intrathecal 100 μg clonidine and alfentanil both can be used for postoperative analgesia without leading any significant hemodynamic and respiratory depression and clonidine is superior to alfentanil in this respect.