Low-dose clozapine-induced seizure: A case report
Clinical Psychopharmacology and Neuroscience, cilt.15, sa.2, ss.190-193, 2017 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 15 Sayı: 2
- Basım Tarihi: 2017
- Doi Numarası: 10.9758/cpn.2017.15.2.190
- Dergi Adı: Clinical Psychopharmacology and Neuroscience
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.190-193
- Anahtar Kelimeler: Adverse effects, Clozapine, Safety, Seizures
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Seizures are believed to be a dose-dependent side effect of clozapine. In this case report, we describe a patient who had tonic-clonic seizures after using a low dose clozapine who did not have any seizure risk. The 29-year-old male patient had been followed-up with a diagnosis of schizophrenia for about 5 years. When using clozapine 200 mg/day he had a tonic-clonic seizure with bilateral diffuse epileptic activity in electroencephalography (EEG). In the literature, there are a few case reports about low-dose clozapine-induced seizure. Seizures were observed in our case with a low dose of clozapine (200 mg/day) making this case remarkable. EEG monitoring at regular intervals and examination of plasma levels of clozapine could be useful in preventing the development of seizures.