Methylphenidate increases cGMP levels in rat brain
Klinik Psikofarmakoloji Bulteni, cilt.15, sa.1, ss.1-4, 2005 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 15 Sayı: 1
- Basım Tarihi: 2005
- Dergi Adı: Klinik Psikofarmakoloji Bulteni
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.1-4
- Anahtar Kelimeler: cGMP, Methylphenidate, Secondary messenger
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Methylphenidate (MPH) is commonly and effectively used to treat children and adolescents with attention-deficit hyperactivity disorder. However, MPH still poses a number of questions on which mechanisms of effect it has on the brain. The present study addresses the question of whether MPH induces cyclic guanosine 3′,5′-monophosphate (cGMP) in rat brain. Methods: MPH at a dose of 10mg/kg p.o. was administered to rats daily for 8 weeks, whereas control rats were given distilled water. The level of cGMP was measured in total brains of the rats. Results: Brain cGMP levels were higher in the study group when compared with the control group (p=0.004). Conclusions: Our results suggested that the long term MPH administration might increase cGMP activity in rat brain.