Evaluation of chromosomal abnormalities and y-chromosome microdeletions in 1696 turkish cases with primary male infertility: A single-center study
Turkish Journal of Urology, cilt.46, sa.2, ss.95-100, 2020 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 46 Sayı: 2
- Basım Tarihi: 2020
- Doi Numarası: 10.5152/tud.2019.19156
- Dergi Adı: Turkish Journal of Urology
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.95-100
- Anahtar Kelimeler: AZF regions, chromosomal abnormalities, multiplex PCR, primary male infertility, Y-chromosome microdeletion
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: The aim of this study was to determine the frequencies of chromosomal abnormalities and Ychromosome microdeletions in Turkish cases with primary male infertility in a single center. Material and methods: Chromosomal abnormalities and Y-chromosome microdeletions were investigated in 1696 cases with primary male infertility between 2012 and 2017. Karyotype analyzes and Y-chromosome microdeletions analyzes [azoospermia factor (AZF) regions] were performed in all cases by using standard cytogenetic methods and the multiplex polymerase chain reaction method, respectively. Results: Chromosomal abnormalities were found in 142 cases (8.4%; 142/1696). Y-chromosome microdeletions were detected in 46 cases (2.7%; 46/1696). Y-chromosome microdeletions in the AZFc region were found in 20 of 46 cases (43%). Conclusion: This study is one of the few were a large number of cases was studied in Turkey. It indicates that cytogenetic and Y-chromosome microdeletion studies should be conducted in cases with primary male infertility prior to selecting assisted reproductive techniques.