Association between thalassemia trait and insulin resistance
Acta Medica Mediterranea, cilt.34, sa.2, ss.321-327, 2018 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 34 Sayı: 2
- Basım Tarihi: 2018
- Doi Numarası: 10.19193/0393-6384_2018_2_51
- Dergi Adı: Acta Medica Mediterranea
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.321-327
- Anahtar Kelimeler: Insulin resistance, Thalassemia minor, Thalassemia trait
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Introduction: One of the subjects discussed in the patients with thalassemia major and thalassemia intermedia is whether excess iron deposition in the liver causes insulin resistance or not. As well, patient group with thalassemia trait (minor) is considered as iron deficiency anemia erroneously in daily practice and this group is subjected to excess iron treatment unnecessarily. In this study, if unnecessary iron load in the patients with thalassemia minor had any effect on insulin resistance was assessed. Materials and methods: A two-hour oral glucose tolerance test (OGTT) was performed in 30 thalassemia carrier patients and 30 gender-age-history matched healthy individuals. Glucose and insulin levels were measured at time zero, 30, 60, 90 and 120 minutes. Homeostasis model assessment of insulin resistance (HOMA-IR), whole-body insulin sensitivity index (WBISI), were calculated and the association between acute phase reactant C-reactive protein (CRP) and insulin resistance was investigated. Results: There was no significant difference between study group and control group with respect to age, gender and body mass index (BMI) parameters. Insulin resistance (IR) parameters were compared within two groups and no statistical significance was determined. Groups were classified in two subgroups according to BMI value: Subgroups with BMI >25 kg/m2 and subgroups with BMI<25 kg/m2. When considered with respect to same BMI values, there was no difference between patient and control groups regarding glucose metabolism parameters and CRP levels. Insulin resistance was more evident inherently regarding BMI difference. Conclusion: It was concluded that glucose metabolisms in patients with thalassemia trait did not show difference compared to BMI-matched healthy individuals. Detecting insulin resistance to be increased in both groups as BMI increased was suggestive of main factor causing disturbances in glucose metabolism in the patients thalassemia trait was obesity.