Association between the development of diabetic foot and serum fetuin-A levels
Polskie Archiwum Medycyny Wewnetrznej, cilt.123, sa.10, ss.513-518, 2013 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 123 Sayı: 10
- Basım Tarihi: 2013
- Doi Numarası: 10.20452/pamw.1921
- Dergi Adı: Polskie Archiwum Medycyny Wewnetrznej
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.513-518
- Anahtar Kelimeler: Diabetic foot, Fetuin-A
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Introduction Fetuin-A is a glycoprotein secreted from hepatocytes, which affects diabetes and peripheral arterial disease. However, there has been no studies regarding the relation between diabetic foot and fetuin-A levels. Objectives We aimed to analyze the association between diabetic foot development and serum fetuin-A levels. Patient s and methods Following the approval of the local ethical board, 137 patients were included in the study. Patients were divided into 3 groups: diabetes group (n = 49), diabetic foot group (n = 57), and control group (n = 31). In all patients, serum fetuin-A, C-reactive protein, magnesium, and hemoglobin A1c (HbA1c) levels were measured. Diabetic foot wounds were classified according to the Wagner classification and lower extremity arteries were evaluated by ultrasonography. Result s Median fetuin-A levels in patients with diabetic foot were significantly higher than in those with diabetes. However, the differences in HbA1c levels between both groups were not statistically significant. A positive correlation was found between the Wagner classification and ultrasound evaluation of the peripheral arteries (degree of atherosclerosis) in patients with diabetic foot. In the diabetic foot group, fetuin-A levels were also found to be positively correlated with ultrasound evaluation. Conclusions We observed a positive correlation between serum fetuin-A levels and the development of diabetic foot. Copyright by Medycyna Praktyczna, Kraków 2013.