Relation of chronic atrophic gastritis and intestinal metaplasia with helicobacter pylori and tumor necrosis factor-α and macrophage migration inhibitory factor polymorphisms in a population of Easten Anatolia Türkiye’de bir doğu populasyonunda kronik atrofik gastrit ve intestinal metaplazi ile tümör nekrozis faktör-α ve makrofaj migrasyon inhibitör faktör gen polimorfizmleri ve Helikobakteri pilorinin ilişkisi
Goztepe Tip Dergisi, cilt.29, sa.1, ss.12-19, 2014 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 29 Sayı: 1
- Basım Tarihi: 2014
- Doi Numarası: 10.5222/j.goztepetrh.2014.012
- Dergi Adı: Goztepe Tip Dergisi
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.12-19
- Anahtar Kelimeler: Chronic atrophic gastritis, Gene polymorphisms, Helicobacter pylori, Intestinal metaplasia, Macrophage migration inhibitory factor, Tumor necrosis factor- α
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Objective: We aimed to determine the effects of tumour-necrosis factor-α (TNF-α) and macrophage migration inhibitory factor (MIF) gene polymorphisms, Helicobacter pylori (H. pylori) infection, on the risk of developing chronic atrophic gastritis (CAG) and intestinal metaplasia (IM). Material and Method: The TNF-α-308G/A and MIF-173G/C single nucleotide polymorphisms (SNPs) were genotyped using polymerase-chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis, in 84 patients (43 CAG and 41 IM) and 40 healthy controls in a region of Eastern Anatolia. Results: An increased risk of CAG was found in subjects with TNF-α-308 GA genotype, negative for H. pylori infection or TNF-α-308 AA genotype carriers and negative for H. pylori infection. An elevated risk of IM was found in subjects with TNF-α-308 GA genotype and negative for H. pylori infection or TNF-α-308 AA genotype and negative for H. pylori infection. An increased risk of CAG was found in subjects with TNF-α-308GA genotype , and positive for H. pylori infection. An increased risk of CAG was found in subjects with MIF-173GC genotype and negative for H. pylori infection or MIF-173CC genotype carriers and negative for H. pylori infection. An elevated risk of IM was found in subjects with MIF-173GC genotype and negative for H. pylori infection. An elevated risk of IM was found in subjects with MIF-173GC genotype and positive for H. pylori infection. Conclusion: Therefore, the TNF-α-308G/A and MIF-173G/C genotyping may be used as biomarkers at the early stage of the gastric cancer.