The syndrome of inappropriate secretion of antidiuretic hormone and hyponatremia due to sodium valproate treatment; a case report and review of the literature Sodyum valproat tedavisine bağlı gelişen uygunsuz antidiüretik hormon salınımı sendromu ve hiponatremi: Bir olgu sunumu ve literatürün gözden geçirilmesi
Yeni Symposium, cilt.56, sa.4, ss.18-21, 2018 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 56 Sayı: 4
- Basım Tarihi: 2018
- Doi Numarası: 10.5455/nys.20190104035535
- Dergi Adı: Yeni Symposium
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.18-21
- Anahtar Kelimeler: Bipolar disorder, Hyponatremia, Sodium valproate, Syndrome of inappropriate secretion of antidiuretic hormone
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Hyponatremia is defined as a serum sodium level of <135 mEq/l, and it is an important clinical entity that increases mortality and morbidity when not treated. Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is the most common cause of the normovolemic hyponatremia. SIADH may occur in a variety of clinical entity and also as an adverse effect secondary to many drugs. Sodium valproate, an agent widely used for the treatment of schizoaffective disorder, bipolar disorder and epilepsy, rarely cause SIADH and hyponatremia as an adverse effect. The mechanism of sodium valproate associated SIADH and hyponatremia is not exactly known. We aimed to present a case of hyponatremia and SIADH due to repeated use of sodium-valproate and to review the relevant literature.