Baclofen withdrawal syndrome in a patient with intrathecal baclofen pump Intratekal Baklofen Pompasi Kullanan Bir Hastada Baklofen Yoksunluǧu Sendromu
Turkiye Fiziksel Tip ve Rehabilitasyon Dergisi, cilt.51, sa.2, ss.74-77, 2005 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 51 Sayı: 2
- Basım Tarihi: 2005
- Dergi Adı: Turkiye Fiziksel Tip ve Rehabilitasyon Dergisi
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.74-77
- Anahtar Kelimeler: Baclofen withdrawal syndrome, Intrathecal baclofen treatment, Spasticity
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Spasticity is a complication characterized by hyperactive stretch reflexes and affects the activities of daily living and quality of life of spinal cord injured patients. Physical modalities and several drug treatments are used in spasticity with spinal cord origin. Baclofen which can hardly pass through the blood-brain barrier is the most commonly used drug in spasticity with spinal cord origin. Intrathecal baclofen treatment is an effective treatment alternative in severe spasticity, and in patients unresponsive to oral treatment and those with intolerable to side effects. However, serious complications can rarely happen during intrathecal baclofen treatment. The most serious one is baclofen withdrawal syndrome. This syndrome is frequently characterized with hyperthermia, pruritis and hypertonicity. But it can sometimes clinically progress to fatal conditions like multisystem failure, rhabdomyolysis, neuroleptic malign syndrome, cardiac failure, cardiac dysrhythmias, disseminated intravascular coagulopathy and sepsis. In this article, a patient with baclofen withdrawal syndrome manifesting recurrent autonomic dysreflexia attacks during intrathecal baclofen treatment is presented. Indications:1 patient with spasticity. Patients:One 23-year-old male patient. TypeofStudy:This study described the development of Lioresal withdrawal syndrome in a patient receiving intrathecal Lioresal for the treatment of spasticity. Case report. DosageDuration:Dosage (given intrathecally via an infusion pump) and duration cannot be ascertained (text in Turkish language). Results:During intrathecal Lioresal treatment, the patient developed Lioresal withdrawal syndrome manifested by recurrent autonomic dysreflexia attacks. AdverseEffects:One patient developed Lioresal withdrawal syndrome manifested by recurrent autonomic dysreflexia attacks.