Effects of systemic used prostaglandin E1 on intraocular pressure
Turk Oftalmoloji Gazetesi, cilt.23, sa.6, ss.457-463, 1993 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 23 Sayı: 6
- Basım Tarihi: 1993
- Dergi Adı: Turk Oftalmoloji Gazetesi
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.457-463
- Anahtar Kelimeler: Intraocular pressure, Prostaglandin E1
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Prostaglandins have a dual, dose dependent effect on intraocular pressure when it is used topical in humans and intracameral and systemic in animals. In order to determine their effect when it is given systemically, 5 patients with Buerger disease were included in the study (we observed 5 patients with Buerger disease in the study). They presented with an ischaemic gangrene at their toes and because of this they had been treated with three different concentrations of PGE1. Before administration of PGE1, routine eye examinations were performed and intraocular pressures were measured every two hours (right and left eye). There were no pathologic findings during the examinations. 1 amp PGE1 was administered by intermittent infusions in three different durations into the femoral artery every day at the same time (161 ng/min, 217 ng/min, 329 ng/min). Intraocular pressures were measured before administration, every 15 minutes during the administration and at the 3rd, 6th, and 10th hours after the administration. When we compared ocular tensions, in spite of hypertension, there was almost in variably decreases in eye pressures during and after the course of injection. As the infusion rate was increased the difference between the decreases in both eyes was reduced. Statistically measuring full decreases were detected in earlier periods. In the measurements taken at the 10th hours intraocular pressures were found to be decreased compared to the values taken premedically. Intraocular pressure decreases observed were thought to differ from the normal daily intraocular pressure variations.