Carbonic anhydrase inhibitory properties of some uracil derivatives
Journal of Enzyme Inhibition and Medicinal Chemistry, cilt.32, sa.1, ss.74-77, 2017 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 32 Sayı: 1
- Basım Tarihi: 2017
- Doi Numarası: 10.1080/14756366.2016.1235043
- Dergi Adı: Journal of Enzyme Inhibition and Medicinal Chemistry
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.74-77
- Anahtar Kelimeler: Carbonic anhydrase, hydroxyl, inhibitor, uracil derivatives
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Inhibitors of carbonic anhydrase (CA) have been carried out in many therapeutic applications, especially antiglaucoma activity. In this study, we investigated some uracil derivatives (4–12) to inhibit human CA I (hCA I) and II (hCA II) isoenzymes. The KI values of the compounds 4–12 are in the range of 0.085–428 µM for hCA I and of 0.1715–645 µM against hCA II, respectively. It is concluded from the kinetic investigations, all compounds used in the study act as competitive inhibitors with substrate, 4-NPA. Uracil derivatives are emerging agents for the inhibiton of carbonic anhydrase which could be used in biomedicine.