Factors predicting recurrence in non-muscle invasive bladder cancers
Gulhane Medical Journal, cilt.63, sa.3, ss.175-180, 2021 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 63 Sayı: 3
- Basım Tarihi: 2021
- Doi Numarası: 10.4274/gulhane.galenos.2021.1472
- Dergi Adı: Gulhane Medical Journal
- Derginin Tarandığı İndeksler: Scopus, Academic Search Premier, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.175-180
- Anahtar Kelimeler: Bladder cancer, carcinoma in situ, survival, tumor recurrence, urothelial cancer
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aims: We aimed to assess patients with non-muscle invasive bladder cancer (NMIBC) to find out the factors affecting recurrence after initial treatment. Methods: In this retrospective cohort study, we investigated patients who underwent transurethral bladder tumor resection (TURB) between January 2014 and April 2020. Patients’ age, gender, initial symptoms, time from the initial symptoms to hospital admission, history of systemic diseases, smoking history, pathological features, intra-vesical treatment records and information about recurrence were recorded. Recurrence was considered as any tumor development other than the aforementioned residual tumor. Results: A total of 103 patients (mean±SD age: 68.5±9.1 years; 93 men and 10 women) were evaluated. The mean diameter of the tumors was 3±1.6 cm. Following the initial TURB and/ or re-TURB, 28 (27.1%) patients underwent induction chemotherapy or BCG therapy. Residual tumor was detected in 35 (34%) patients who were either detected within the first three months following the TURB, without receiving any intravesical therapy, or in re-TURB performed for the purpose of resection of the residual visible bulky lesions following an incomplete initial resection. Eleven patients (10.6%) recurred within a median of 18 months of follow-up. The median recurrence-free survival was 25 months (95% confidence interval (CI): 16.5-33.4). The presence of carcinoma in situ (CIS) [Hazard ratio (HR): 3.00, 95% CI: 1.2-7.6, p=0.03], female gender (HR: 2.38, 95% CI: 1.03-5.4, p=0.03) and age >70 years (HR: 1.87, 95% CI: 1.02-3.41, p=0.03) were significantly associated with recurrence. Conclusions: The present study showed that the presence of CIS, female gender, and age >70 years were independently associated with the recurrence of NMIBC.