Hypersensitivity reactions to proton pump inhibitors. An EAACI position paper
Allergy: European Journal of Allergy and Clinical Immunology, cilt.79, sa.3, ss.552-564, 2024 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 79 Sayı: 3
- Basım Tarihi: 2024
- Doi Numarası: 10.1111/all.15961
- Dergi Adı: Allergy: European Journal of Allergy and Clinical Immunology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.552-564
- Anahtar Kelimeler: allergy, anaphylaxis, drug hypersensitivity, hypersensitivity reaction, proton pump inhibitors
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Proton pump inhibitors (PPIs) are invaluable therapeutic options in a variety of dyspeptic diseases. In addition to their well-known risk profile, PPI consumption is related to food and environmental allergies, dysbiosis, osteoporosis, as well as immediate and delayed hypersensitivity reactions (HSRs). The latter, although a rare event, around 1%–3%, due to the extraordinarily high rate of prescription and consumption of PPIs are related to a substantial risk. In this Position Paper, we provide clinicians with practical evidence-based recommendations for the diagnosis and management of HSRs to PPIs. Furthermore, the unmet needs proposed in the document aim to stimulate more in-depth investigations in the topic.