Strontium and fluorine co-doped biphasic calcium phosphate: Characterization and in vitro cytocompatibility analysis
Biomedical Physics and Engineering Express, cilt.3, sa.4, 2017 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 3 Sayı: 4
- Basım Tarihi: 2017
- Doi Numarası: 10.1088/2057-1976/aa768c
- Dergi Adı: Biomedical Physics and Engineering Express
- Derginin Tarandığı İndeksler: Scopus
- Anahtar Kelimeler: biphasic calcium phosphate, co-doping, strontium, fluorine, characterization, hardness, cytocompatibility
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Strontium (Sr2+) and fluoride (F-) ions are known to play an important role in bone and tooth metabolism. In this work, we prepare biphasic calcium phosphate (BCP) bioceramics co-doped with different fractions of Sr2+ and F- ions to investigate the impact of dopant on the crystal structure and biological properties of BCP bioceramics. The materials were successfully synthesized using a wet precipitation method, followed by sintering at 1100°C for 1 h. The sintered materials were characterized using x-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy and field emission scanning electron microscopy (FESEM). XRD analysis revealed that the BCP bioceramics were composed of hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP), along with calcium oxide (CaO) as impurity. Furthermore, the percentage of β-TCP tended to increase with an increase in the Sr2+ ion concentration. The lattice parameters of HA phase expanded along with incorporation of Sr2+ and F- ions. The morphology of the yielding materials demonstrated that the incorporation of Sr2+ and F- ions caused a decrease in the grain size. The Vickers hardness (HV) test showed that hardness values increased with increasing Sr2+ concentrations. In vitro cell culture tests were performed with human osteogenic sarcoma (Saos-2) cell line. Saos-2 cells attached and proliferated faster on Sr/F-BCP materials compared to pure BCP, showing that Sr/F-BCP materials were cytocompatible.