Development and Characterization of Indomethacin Quantum Dot Loaded Hydrogel İndometazin Kuantum Nokta Yüklü Hidrojelin Geliştirilmesi ve Karakterizasyonu

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Çamlik G., Karaotmarli Güven G., Bi̇Lakaya B., ÇAĞLAR E. Ş., BORAN T., ÜSTÜNDAĞ OKUR N., ...Daha Fazla

Fabad Journal of Pharmaceutical Sciences, cilt.50, sa.2, ss.343-354, 2025 (Scopus, TRDizin)

Özet

Inflammation occurring in the wound tissue plays an important role in wound healing. This situation can cause undesirable conditions such as pain and swelling in patients. Indomethacin (IM) is one of the most frequently preferred nonsteroidal anti-inflammatory (NSAID) active substances that suppress the inflammatory response. Indomethacin blocks prostaglandin synthesis by inhibiting the cyclooxygenase enzyme and thus helps support the wound healing process. This study includes hydrogel formulations of quantum dots (IMQDs) prepared from the indomethacin active substance for the first time. Characterization studies of the prepared IMQDs were carried out and particle sizes, % polydispersity indexes, and zeta potentials were measured as 8.53±0.096 nm, 19.49±0.550 %, -8.2±0.781 mV, respectively. Quantum yield % was calculated as 56.48%. Hydrogel formulations containing F1 (0.5%), F2 (0.75%), and F3 (1%) containing carbomer at different concentrations and F1-IMQDs, F2-IMQDs and F3-IMQDs containing 2% IMQDs were prepared. The prepared hydrogels’ viscosity, pH, mechanical properties, and spreadability were measured. In vitro release studies of all formulations were performed, and it was seen that the gel drug containing IMQDs exhibited a higher release rate than traditional drugs. At the same time, the gel containing IMQDs showed fluorescent properties. Cell culture studies did not show toxicity. In line with the obtained data, the hydrogel formulations containing IMQDs prepared can be applied to dermal wound healing or anti-inflammatory treatments. This study can be a source for future studies and applications.