Effect of glutamine on bacterial translocation in rats given total parenteral nutrition
Turkish Journal of Surgery, cilt.10, sa.4, ss.193-199, 1994 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 10 Sayı: 4
- Basım Tarihi: 1994
- Dergi Adı: Turkish Journal of Surgery
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.193-199
- Anahtar Kelimeler: Glutamine, Total parenteral nutrition, Translocation
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Bacterial translocation which is observed after trauma, shock, major burns, intestinal obstruction, cholestasis, radiotherapy, total parenteral nutrition is a result of intestinal mucosal disruption and immunological response modification lately, methods preventing bacterial translocation are frequently studied. In this paper the effects of glutamine which is the major fuel of enterocytes, on bacterial translocation are investigated. Three experimental groups (n=10) of male Wistar albino rats are formed in Group I, II, III, received respectively standard laboratory food and water ad libidum, standard total parenteral nutrition and total parenteral nutrition with extra glutamine. All three groups are compared in respect with mesentary lymph node translocation, colonic intraluminal bacterial counts and histologic mucosal integrity. Bacterial translocation rate was observed to be 80% and 10% in Group II and III respectively. No bacterial growth was found in the control mesentary lymph nodes. Colonic intraluminal bacterial counts were found to be significantly increased in Group II and III when compared to control, but the difference within these two was not significant. Histopathologically the mucosal integrity was well kept in Group III, while clear disruption was observed in Group II. The beneficial effect of glutamine during total parenteral nutrition on decreasing bacterial translocation rate was attributed to the preservation of mucosal integrity. Finally it can be concluded that a clinical study investigating glutamine effect on bacterial translocation in the patients receiving total parenteral nutrition is worth consideration.