Gamma/delta T cells in patients with acute brucellosis
Clinical and Experimental Medicine, cilt.9, sa.2, ss.101-104, 2009 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 9 Sayı: 2
- Basım Tarihi: 2009
- Doi Numarası: 10.1007/s10238-008-0021-1
- Dergi Adı: Clinical and Experimental Medicine
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.101-104
- Anahtar Kelimeler: Brucellosis, Gamma/delta T cells
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
We aimed to investigate the population of gamma/delta T (γ/δ T) cells in patients with acute brucellosis. When the bacteria penetrate to the host, the innate immune response aims to prevent the attack by non-activated professional phagocytes. At that moment, macrophages trigger the other cells of the immune system. The cells that can respond immediately are natural killer and γ/δ T cells. The study included 40 cases of acute brucellosis and 20 healthy volunteers. In this study, it was aimed to compare γ/δ and alpha/beta (α/β) receptors of the T cells at pre- and post treatment period of patients diagnosed as brucellosis, especially to evaluate the levels of γ/δ T cells at monitoring of the disease, using flow cytometry. As a result, it was observed that γ/δ T cells significantly increased in peripheral blood in patients with brucellosis compared with the healthy individuals (13.23 ± 4.7 and 5.25 ± 1.4, respectively (p = 0.0001)). γ/δ T cells were significantly decreased after the brucellosis treatment (p < 0.01). The results of the present study indicate that considerable counts of γ/δ T cells are involved in acute brucellosis cases. Our findings suggest that γ/δ TCR bearing cell counts may be used as a supplementary marker for monitoring brucellosis. © 2008 Springer-Verlag.