Successful treatment of ice-rituximab chemotherapy and subsequent bone marrow transplantation in a patient with early-relapse burkitt leukemia and inverted duplication of 1q
Journal of Pediatric Hematology/Oncology, cilt.34, sa.2, 2012 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 34 Sayı: 2
- Basım Tarihi: 2012
- Doi Numarası: 10.1097/mph.0b013e318236b1af
- Dergi Adı: Journal of Pediatric Hematology/Oncology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Anahtar Kelimeler: Burkitt leukemia, inverted duplication of 1q, rituximab, bone marrow transplantation
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Although childhood acute lymphoblastic leukemias are of good prognosis than leukemias of adulthood, some chromosomal abnormalities may have negative effects on their prognosis. Inverted duplication (1q) is a chromosomal abnormality with negative effect on outcome of Burkitt leukemia and lymphomas. We report a case of CD20+ Burkitt leukemia with inverted duplication (1q) mutation, who had an early relapse during NHL-BFM 95 treatment. Two courses of ICE-rituximab treatment were administered after relapse and a successful HLA-full match bone marrow transplantation was carried out. He is in follow-up for 18 months without any problem after the bone marrow transplantation. We suggest the usage of ICE protocol combined with rituximab in childhood CD20 + Burkitt leukemia with poor prognostic criteria such as inverted duplication (1q) mutation. Copyright © 2011 by Lippincott Williams & Wilkins.