Comparative analysis of adenovirus and rotavirus gastroenteritis: insights into inflammatory response and temporal variations
Frontiers in Pediatrics, cilt.13, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 13
- Basım Tarihi: 2025
- Doi Numarası: 10.3389/fped.2025.1523531
- Dergi Adı: Frontiers in Pediatrics
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, Directory of Open Access Journals
- Anahtar Kelimeler: children, rotavirus, adenovirus, mean platelet volume, neutrophil/lymphocyte value, gastroenteritis
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: Acute viral gastroenteritis remains a leading cause of healthcare costs globally, prompting the need for effective yet simple diagnostic strategies. This study aimed to comprehensively examine the demographic, clinical, and seasonal characteristics, hemogram parameters, and C-reactive protein levels in children diagnosed with adenovirus and rotavirus gastroenteritis. Methods: By conducting a retrospective study, three groups of children diagnosed with gastroenteritis (Rotavirus positive, adenovirus positive, and rota/adenovirus negative group) were compared in terms of demographic, clinical, and laboratory parameters. Results: Among 265 children with gastroenteritis, 59.6% were under 36 months, and 36.8% of this group tested positive for rotavirus, while 30% of them tested positive for adenovirus. A statistically significant association was observed between rotavirus gastroenteritis and high neutrophil/lymphocyte value (2.76 ± 1.52) and decreased mean platelet volume (7.47 ± 0.36 fL). Temporal analysis revealed numerical peaks in the adenovirus group in summer and rotavirus in winter; however, these differences were not statistically significant (p = 0.684, 0.851). Unlike rotavirus, our study did not reveal any prominent laboratory marker that serves as a distinctive feature of adenovirus. Conclusions: Our findings suggested that decreased mean platelet volume and high neutrophil/lymphocyte ratio were found statistically significant in rotavirus gastroenteritis, distinguishing it from other causes of acute gastroenteritis.