Mean platelet volume and solitary parathyroid adenoma
International Journal of Clinical and Experimental Medicine, cilt.9, sa.7, ss.14536-14541, 2016 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 9 Sayı: 7
- Basım Tarihi: 2016
- Dergi Adı: International Journal of Clinical and Experimental Medicine
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.14536-14541
- Anahtar Kelimeler: Parathyroid, adenoma, MPV, platelet
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: Hyperparathyroidism (HPT) is a common endocrine disorder. 85% of patients with primary HPT harbor a single adenoma and cured by excision of the incident gland. Mean platelet volume (MPV) shows the average size of platelets and reflects the platelet production rate and stimulation. We decided to investigate whether MPV would be a useful biomarker in patients with parathyroid adenoma. Materials and Methods: Fourty-four patients with solitary parathyroid adenoma (Adenoma group) and 56 people with normal serum PTH and calcium levels (Control group) were included in the study. The differences in pre-treatment MPV between adenoma group and healthy control group were investigated. The differences between pre-operative and post-operative MPV, PTH, and calcium levels in adenoma group were also analyzed. Results: There was no statistically significant difference between the adenoma group and healthy control group regarding age; gender; smoking status; and white blood cell, hemoglobin, and platelet count (P > 0.05). Post-operative MPV, PTH, and serum calcium levels in patients with solitary parathyroid adenoma (SPA) were found to be significantly lower when compared with pre-operative MPV, PTH, and serum calcium level (P = 0.001). Pre-operative MPV levels in patients with SPA were found to be significantly higher when compared with healthy control group (P = 0.0001). For the diagnosis of SPA, ROC analysis revealed 76.1% sensitivity and 80.4% specificity for a cut-off value of 9.015 fl of MPV whereas positive predictive was 76.1% and negative predictive value was 83.3%. Conclusion: In this study, a significant correlation of MPV level with parathyroid adenoma was found. Therefore, detecting MPV level would be useful for the diagnosis of SPA.