Association between vaginal 70-kd heat shock protein, interleukin-1 receptor antagonist, and microbial flora in mid trimester pregnant women
American Journal of Obstetrics and Gynecology, cilt.192, sa.3, ss.916-921, 2005 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Özet
- Cilt numarası: 192 Sayı: 3
- Basım Tarihi: 2005
- Doi Numarası: 10.1016/j.ajog.2004.09.023
- Dergi Adı: American Journal of Obstetrics and Gynecology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.916-921
- Anahtar Kelimeler: 70-kd heat shock protein, cytokine, vaginal microflora, pregnancy, bacterial vaginosis
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Objective: This study investigated the association among the inducible 70-kd heat shock protein, cytokines, and microbial flora in the vagina in mid trimester pregnant women and subsequent preterm delivery. Study design: Vaginal samples from 205 pregnant women, which were collected at 18 to 22 weeks of gestation, were analyzed for qualitative and quantitative vaginal microflora and for 70-kd heat shock protein, interleukin-1β, interleukin-1 receptor antagonist, and tumor necrosis factor-α by enzyme-linked immunosorbent assay. Pregnancy outcome data were obtained subsequently. Results: The 70-kd heat shock protein was detected in 38 vaginal samples (18.5%). Its presence was associated with elevated vaginal pH, a diagnosis of bacterial vaginosis, and elevated interleukin-1 receptor antagonist levels (P <. 001). Among women with bacterial vaginosis, 70-kd heat shock protein-positive subjects had a >80% increase in median vaginal concentration of interleukin-1 receptor antagonist (P <. 05). Conclusion: Vaginal 70-kd heat shock protein expression is associated with the down-regulation of the proinflammatory immune response to abnormal vaginal flora in mid trimester pregnant women. © 2005 Elsevier Inc. All rights reserved.