Assessment of autonomic dysfunction in primary Sjögren’s syndrome: A combined evaluation using sympathetic skin response and COMPASS 31
Irish Journal of Medical Science, cilt.195, sa.1, ss.395-399, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 195 Sayı: 1
- Basım Tarihi: 2026
- Doi Numarası: 10.1007/s11845-025-04174-1
- Dergi Adı: Irish Journal of Medical Science
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest)
- Sayfa Sayıları: ss.395-399
- Anahtar Kelimeler: Sj & ouml;gren syndrome, Autonomic, Sympathetic skin response, COMPASS 31
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disorder predominantly affecting exocrine glands, with symptoms including dry eyes and mouth. Involvement of the autonomic nervous system (ANS) has been reported, though data on its frequency and clinical significance remain inconsistent. This study aimed to evaluate autonomic dysfunction in patients with pSS using Sympathetic Skin Response (SSR) and the Composite Autonomic Symptom Score 31 (COMPASS 31). Methods: Fifty-nine female pSS patients and 38 age-matched healthy controls were enrolled. All participants underwent neurological examination, nerve conduction studies, and SSR testing. Autonomic symptoms were assessed using the COMPASS 31 questionnaire. Disease activity in pSS patients was evaluated with the EULAR Sjögren’s Syndrome Disease Activity Index (ESSDAI). Results: SSR latency and amplitude values were not significantly different between pSS patients and healthy controls. However, total COMPASS 31 scores and all subdomain were significantly higher in the patient group. A strong positive correlation was observed between COMPASS 31 and ESSDAI scores (r = 0.68, p < 0.001). Conclusion: The findings suggest that autonomic symptoms are common in pSS and are associated with disease activity, as reflected by COMPASS 31 scores. However, SSR measurements did not show corresponding abnormalities, possibly due to the absence of vasculitis or ganglionopathy, ongoing treatment. SSR may not be sufficient as a standalone tool to detect autonomic dysfunction in pSS.