Case–Controlled Clinical Assessment of the Olfactory System via Cranial Magnetic Resonance Imaging in Patients With Type 2 Diabetes Mellitus
Brain and Behavior, cilt.16, sa.1, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 16 Sayı: 1
- Basım Tarihi: 2026
- Doi Numarası: 10.1002/brb3.71210
- Dergi Adı: Brain and Behavior
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals, Academic Search Ultimate (EBSCO), Health Research Premium Collection (ProQuest)
- Anahtar Kelimeler: diabetes mellitus, magnetic resonance imaging, olfactory bulb volume, olfactory sulcus depth, olfactory tract length
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: The purpose of this study is to assess the olfactory system of patients with T2DM using the cranial magnetic resonance imaging (MRI) method. Method: This is a retrospective case–control study in which a group of T2DM patients and a control group were compared. The results of the examinations of the olfactory systems of the patients by cranial MRI were transferred to a data collection form. Descriptive statistical methods, chi-squared tests, the Mann–Whitney U test, and Spearman's correlation coefficient were used to analyze the data. Results: It was determined that 66.7% of the case group were women, the mean age of the patients in the group was 52.50 ± 7.41, and their mean T2DM diagnosis duration was 6.48 ± 3.18 years. There were statistically significant differences between the case and control groups in terms of their olfactory bulb volume (OBV), olfactory tract length (OTL), and olfactory sulcus depth (OS) values. Longer T2DM durations and elevated HbA1c levels were significantly associated with structural disorders of the olfactory system (p < 0.01). Conclusion: A longer duration of T2DM and elevated HbA1c levels trigger the structural disorders of the olfactory system. In comparison to healthy controls, we identified prominent changes in the olfactory bulb volumes, olfactory tract lengths, and olfactory sulcus depths of T2DM patients. This reveals the need for T2DM patients to pay more attention to their diet and insulin treatment. Similarly, olfactory dysfunction in T2DM patients should be carefully monitored by clinicians.