Comparison of the diagnostic accuracy of [68Ga]Ga-Trivehexin PET/computed tomography and [18F]FDG PET/computed tomography in nodal staging of various solid tumors
Nuclear Medicine Communications, cilt.47, sa.4, ss.470-478, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 47 Sayı: 4
- Basım Tarihi: 2026
- Doi Numarası: 10.1097/mnm.0000000000002109
- Dergi Adı: Nuclear Medicine Communications
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
- Sayfa Sayıları: ss.470-478
- Anahtar Kelimeler: [F-18]FDG, [Ga-68]Ga-Trivehexin, PET/computed tomography, nodal staging
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective – The aim of this retrospective study is to evaluate the diagnostic accuracy of [68Ga]Ga-Trivehexin PET/CT compared with [18F]fluorodeoxyglucose (FDG) PET/computed tomography (CT) for nodal staging in various solid tumors. Materials and methods – Between 2024 and 2025, a total of 15 patients with histopathologically confirmed primary or recurrent cancer were enrolled in the study. All participants underwent both [18F]FDG and [68Ga]Ga-Trivehexin PET/CT imaging for oncologic staging. Imaging findings were compared with histopathological results and clinical/radiological follow-up. Primary tumors, lymph nodes, and metastases were visually assessed, and maximum standardized uptake values were calculated. Results – The median age of the patients was 62 years. Diagnoses included colorectal, breast, pancreatic, lung, bladder, thyroid, and endometrial cancers. Both [18F]FDG and [68Ga]Ga-Trivehexin PET/CT demonstrated uptake in all primary tumors. While [18F]FDG PET/CT showed uptake in all lymph nodes, [68Ga]Ga-Trivehexin PET/CT demonstrated positive uptake only in metastatic lymph nodes. The positive predictive value of [68Ga]Ga-Trivehexin PET/CT was calculated as 100%. In contrast, [18F]FDG PET/CT exhibited lower specificity, with a positive predictive value of 26.3%. Conclusion – This study demonstrates that [68Ga]Ga-Trivehexin PET/CT offers higher specificity than [18F]FDG PET/CT, particularly in benign lymph node lesions, and is effective in accurately identifying metastatic lymph nodes. Compared to [18F]FDG PET/CT, 68Ga-Trivehexin PET/CT provides lower false-positive rates and higher diagnostic accuracy, potentially reducing the need for unnecessary invasive procedures.