Relationship between systemic inflammatory response index, systemic immune inflammation index and neutrophil-lymphocyte ratio in patients undergoing intracranial aneurysm surgery
Pakistan Journal of Medical Sciences, cilt.42, sa.11, ss.2942-2948, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 42 Sayı: 11
- Basım Tarihi: 2026
- Doi Numarası: 10.12669/pjms.42.11.16174
- Dergi Adı: Pakistan Journal of Medical Sciences
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, Directory of Open Access Journals, Academic Search Ultimate (EBSCO), Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest)
- Sayfa Sayıları: ss.2942-2948
- Anahtar Kelimeler: Aneurysm surgery, Indices, Mortality
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objectives: We aimed to investigate the relationship between Systemic Inflammatory Response Index (SIRI), Systemic Immune Inflammation Index (SII), Neutrophil Lymphocyte Ratio (NLR) and mortality in intracranial aneurysm surgery patients, and evaluate their predictive value for mortality. Methodology: Patients who underwent intracranial aneurysm surgery between April 2013 and April 2022 at a single center were retrospectively included with the approval of the Health Sciences University Fatih Sultan Mehmet Training and Research Hospital Clinical Research Ethics Committee (2022/55). Demographics, aneurysm characteristics, intensive care and mechanical ventilation requirements, and mortality status were recorded. SIRI, SII, and NLR were recorded preoperatively, on the 7th postoperative day, and at discharge. The predictive value for mortality was assessed with logistic regression and ROC analysis. Results: In 286 included patients, the mortality rate was 13.3%. Patients with mortality had higher SIRI, SII, and NLR than survivors at all time points. NLR on postoperative day seven had the highest predictive power for mortality, followed by SIRI and SII. Logistic regression analysis showed postoperative day seven NLR, SIRI, and SII as significant predictors of mortality. NLR and SIRI were strong prognostic indicators, increasing mortality risk by 5.57 and 4.97 times above their cut-off values, respectively. Inflammatory markers were higher in ruptured aneurysm patients across all time periods. Conclusion: SIRI, SII, and NLR were associated with mortality in intracranial aneurysm surgery patients. NLR on postoperative day seven emerged as a strong predictor of mortality. These accessible and non-invasive inflammatory indices could be useful for risk assessment in clinical practice.