Evaluation of the Therapeutic Efficacy of Herbal Mixture, Cystolyberin, on E.coli J96-induced Bacterial Cystitis in Rats
Van Medical Journal, cilt.32, sa.4, ss.324-330, 2025 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 32 Sayı: 4
- Basım Tarihi: 2025
- Doi Numarası: 10.5505/vmj.2025.50469
- Dergi Adı: Van Medical Journal
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.324-330
- Anahtar Kelimeler: cystitis, escherichia coli, experimental model, herbal, Medicine
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Introduction: This study aimed to evaluate the effects of the herbal compound, Cystolyberin, on the treatment of bacterial cystitis in a ra t model. Materials and Methods: Twenty-eight male Sprague-Dawley rats were divided into four groups. Group 1 was the sham group, Group 2 served as the control, Group 3 received a short course of Cystolyberin, and Group 4 received an extended course. Bladder tiss ues and urine samples were collected after treatment. Urine culture results and histopathological findings were compared bet ween the groups to assess the therapeutic effects of Cystolyberin. Results: Urine cultures showed no E. coli in Groups 1 and 4, while 100% of Group 2 and 42.86% of Group 3 had persistent infection. Histopathological analysis revealed a significant reduction in bladder inflammation in Group 4 compared to Group 2. Additionally, there was a significant difference in lamina propria thickness across the groups. No significant differences were found for edema, vascular congestion, epithelial modification, urothelial integrity, or lymphocyte presence. Conclusions: A 14-day course of Cystolyberin led to the eradication of E. coli in the rat model, demonstrating its potential as a treatment for bacterial cystitis. Further studies are needed to confirm these findings.