Pentoxifylline and pentaglobin adjuvant therapies for neonatal nosocomial sepsis in neonates less than 1500g weight
Journal of the Pakistan Medical Association, cilt.67, sa.10, ss.1482-1486, 2017 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 67 Sayı: 10
- Basım Tarihi: 2017
- Dergi Adı: Journal of the Pakistan Medical Association
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1482-1486
- Anahtar Kelimeler: Immunoglobulins, Pentoxifylline, Very low birth weight
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: To compare different support therapies in very low birth-weight preterm neonates with nosocomial sepsis. Methods: This clinical pilot study was conducted at the Bagcilar Research and Training Hospital, Istanbul, Turkey, from September 2015 to November 2016. Preterm infants appropriately sized for a gestational age of < 32 weeks and < 1,500g were included in the study. Pentaglobin was initiated on the day of diagnosis of nosocomial sepsis to very low birth-weight preterm neonates as a support therapy in addition to antibiotics: 5 ml/kg per day of pentaglobin was infused over a four-hour period on three consecutive days. Pentoxifylline α5 mg/kg every 6 hours) was administered to premature infants with sepsis on three successive days. Results: Of the 41 neonates, 19α46.3%) were girls and 22α53.7%) were boys. Vital signs, haematologic tables, peripheral blood smear left shift ratio, and blood-gas parameters did not differ significantly between the groups αp>0.05), but the C-reactive protein αmg/dl) values significantly decreased after pentoxifylline treatment αp<0.05). Coagulase-negative staphylococci were the most frequently isolated bacteria in the two groups αn=4; 19% vs. n=4; 20%). There was no difference in isolated microorganisms. There was no significant difference in intraventricular haemorrhage, necrotising enterocolitis, periventricular leukomalacia or symptomatic patent ductus arteriosus in the neonates when comparing the two groups and no systemic reactions were observed during adjuvant therapy in the preterm neonates αp>0.05). The total duration of hospitalisation was 49.46±13.52 days for the pentaglobin group and 44.21±11.1 days for the pentoxifylline group neonates. Conclusion: Pentoxifylline treatment for nosocomial sepsis decreased C-reactive protein levels and heart rate more than pentaglobin therapy.