Role of CRP, TNF-α and IGF-1 in delirium athophysiology Deliryum patofzyolojisinde CRP, TNF-α ve igf-1’in rolü

Çinar M. A., Balikçi A., SERTOĞLU E., Ak M., SERDAR M. A., ÖZMENLER K. N.

Noropsikiyatri Arsivi, cilt.51, sa.4, ss.376-382, 2014 (SCI-Expanded, Scopus, TRDizin)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 4
  • Basım Tarihi: 2014
  • Doi Numarası: 10.5152/npa.2014.6999
  • Dergi Adı: Noropsikiyatri Arsivi
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.376-382
  • Anahtar Kelimeler: Delirium, CRP, TNF-alpha, IGF-1, DRS-R98-T
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Methods: A total of 93 inpatients that planned to undergo cardiovascular surgery were informed; 35 of them completed the study. Medical history and current cognitive status were evaluated pre-operatively. Participants were followed using Delirium Rating Scale-Revised-98 Turkish (DRS-R98-T) for delirium symptoms, and blood samples were collected post-operatively. Results: Delirium was developed more in participants who had worse pre-operative cognitive status. Also, low pre-operative IGF-1 levels were detected in the delirium group. Pre-operative CRP and TNF-α levels were not different between groups. Conclusion: Low IGF-1 levels can be used to predict delirium after surgery. However, the complex nature of cytokines and delirium itself make it diffcult to utilize cytokines to predict delirium instead of psychometric tools. Introduction: Delirium is a common and life-threatening neuropsychiatric syndrome. Diagnosing delirium can be challenging, which increases mortality and mortality rates and health care costs. The biologic model of delirium is not defnite yet, but evidence supports a cholinergic defciency model. Delirium may be the result of processes and drugs that trespass a compromised blood-brain barrier. We aimed to evaluate the possible diagnostic utilization and the role of certain biomarkers, such as C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), and insulin like growth factor-1 (IGF-1), in delirium etiology.