Meropenem induced mixed hepatocellular and cholestatic hepatitis: A report of two cases
Gulhane Medical Journal, cilt.60, sa.2, ss.64-66, 2018 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 60 Sayı: 2
- Basım Tarihi: 2018
- Doi Numarası: 10.26657/gulhane.00023
- Dergi Adı: Gulhane Medical Journal
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.64-66
- Anahtar Kelimeler: Cholestasis, Drug- induced liver injury, Hepatitis, Meropenem
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Drug-induced liver injury (DILI) is common clinic issue in clinical practice and might be induced by almost all drugs. Antibiotics (especially beta-lactams) are one of the leading cause due to their widespread use. Albeit rare, meropenem may cause DILI, even shortly after its administration. Here we report our experience of two cases with cholestatic hepatitis that occured after meropenem use. In the differential diagnosis of liver enzyme abnormalities after meropenem treatment, physicians should also prompt suspicion of an adverse drug reaction.